HISTORY
Dipotassium Glycyrrhizate has a rich history rooted in ancient China, where it was first extracted from licorice root (Glycyrrhiza glabra) and used in traditional medicine for its soothing and anti-inflammatory properties. Documented as early as the Han Dynasty (206 BCE - 220 CE), licorice root was celebrated for treating ailments like digestive and respiratory issues, as well as skin conditions. Its benefits spread to Europe by the Middle Ages, where it was valued in herbal medicine. Modern science eventually isolated Dipotassium Glycyrrhizate, recognizing it as the key compound behind licorice root's skin-healing benefits, making it a staple in contemporary skincare for its anti-inflammatory, moisturizing, and brightening effects.
SCIENCE
Dipotassium Glycyrrhizate is a salt derived from glycyrrhizic acid, which is found in licorice root. Its unique chemical structure allows it to provide numerous benefits to the skin, making it a popular ingredient in modern skincare formulations. This versatile compound offers anti-inflammatory, moisturizing, brightening, and anti-aging properties.
One of the standout benefits of Dipotassium Glycyrrhizate is its potent anti-inflammatory effect. It works by inhibiting the release of certain enzymes and compounds that trigger inflammation in the skin. This makes it particularly effective in treating conditions like eczema, rosacea, and dermatitis. Studies have shown that Dipotassium Glycyrrhizate can reduce inflammation markers in the skin by up to 50% within two weeks of consistent use, making it especially beneficial for individuals with sensitive or reactive skin.
Dipotassium Glycyrrhizate also aids in maintaining skin hydration. It enhances the skin's natural ability to retain moisture by reinforcing the skin barrier. This action helps prevent water loss, keeping the skin plump and hydrated. According to research, products containing Dipotassium Glycyrrhizate can improve skin hydration levels by up to 30% after just one week of use. This hydrating effect is crucial for maintaining a healthy and glowing complexion.
Another remarkable benefit of Dipotassium Glycyrrhizate is its ability to brighten the skin and reduce hyperpigmentation. It inhibits the production of tyrosinase, an enzyme crucial for melanin synthesis. By doing so, it helps to fade dark spots and even out skin tone. Clinical trials have demonstrated that a 2% concentration of Dipotassium Glycyrrhizate can lighten hyperpigmentation by up to 20% over 12 weeks. This makes it an excellent choice for those looking to achieve a more even and radiant complexion.
Glabridin, a flavonoid found in licorice root, is a significant component contributing to the skin-brightening effects of Dipotassium Glycyrrhizate. It is known for its ability to inhibit the activity of tyrosinase, an enzyme involved in the production of melanin. This inhibition helps reduce pigmentation and results in a more even skin tone. Research has shown that glabridin can effectively reduce UVB-induced pigmentation by up to 50% in guinea pig studies.
Additionally, some studies suggest that glabridin may be more effective than hydroquinone, a common skin-lightening agent, while having fewer side effects. Moreover, glabridin possesses antioxidant properties, protecting the skin from free radical damage and environmental stressors. This contributes to the anti-aging benefits of Dipotassium Glycyrrhizate, helping to maintain skin elasticity and reduce the appearance of fine lines and wrinkles.
REFERENCES
- Fiore, C., Eisenhut, M., Krausse, R., Ragazzi, E., Pellati, D., Armanini, D., & Bielenberg, J. (2011). Anti-inflammatory activities of glycyrrhizic acid and its derivatives. Mini Reviews in Medicinal Chemistry.
- Vitali, R., Palone, F., Pierdomenico, M., Negroni, A., Cucchiara, S., Aloi, M., Oliva, S., & Stronati, L. (2015). Dipotassium glycyrrhizate via HMGB1 or AMPK signaling suppresses oxidative stress during intestinal inflammation. Biochemical Pharmacology, 97(3), 292-299.
- Shin, J., Kwon, S. H., Kim, Y. K., et al. (2017). Inhibitory effect of dipotassium glycyrrhizate on melanogenesis in B16/F10 melanoma cells and the skin of brown guinea pigs. Archives of Dermatological Research, 309(6), 439-447.
